New vistas in transplantationRenal transplantationHyperparathyroidism and New Onset Diabetes After Renal Transplantation
Section snippets
Patients
In a retrospective study, we included all adult kidney allograft recipients with follow-up visits for ≥1 year at the Department of Nephrology and Transplantation, Skåne University Hospital, Malmö and Lund, respectively, between January 2000 and June 2011. A total of 335 patients fulfilled the inclusion criteria. All patients but 1 was transplanted at our center. Altogether, 90 patients were excluded from the study because of DM at the time of transplantation (n = 75), age <18 years (n = 12), or
Results
Out of 245 patients, 36 developed NODAT, yielding a cumulative incidence of 15% during the first year posttransplantation. In 94% of cases, the diagnosis was made within 180 days after transplantation (range, 15–250). Patients with NODAT were treated with insulin (n = 19), oral diabetic agents (n = 5), dietary and exercise counseling (n = 7), or modifications in immunosuppressive therapy only (n = 4) after the diagnosis was made. Information on therapy was missing in 1 case.
Patient
Discussion
Our results show that elevated PTH levels were associated with NODAT in unadjusted regression analysis. This association persisted in the adjusted model including age, sex, and PTH. We found that PTH values above twice the upper limit of the normal range were associated with NODAT. Age was also independently associated with NODAT, in line with previous studies [19], [22].
NODAT is a common complication of renal transplantation [24] and increases the risk of graft failure [25], [26], [27] and
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Cited by (7)
The incidence of new onset diabetes after transplantation and related factors: Single center experience
2017, NefrologiaCitation Excerpt :Primary hyperparathyroidism (pHPT) and secondary hyperparathyroidism are both associated with abnormalities in glucose metabolism, such as glucose intolerance and insufficient insulin release.36–39 Ivarsson et al.40 found that intact parathormone (iPTH) values above twice the upper limit of the normal range were associated with PTDM. Hyperparathyriodism was established as a risk factor for the development of PTDM in our study.
Network-medicine approach for the identification of genetic association of parathyroid adenoma with cardiovascular disease and type-2 diabetes
2023, Briefings in Functional GenomicsPrevalence and risk factors of new-onset diabetes after transplantation (Nodat)
2020, Annals of TransplantationInsights into the association of vitamin d deficiency with parathyroid hormone levels with relevance to renal function and insulin resistance
2019, Current Nutrition and Food Science