Renal transplantationComplication: RenalRenalase, A Novel Regulator of Blood Pressure, Is Predicted by Kidney Function in Renal Transplant Recipients
Section snippets
Materials and Methods
These studies were performed on 80 kidney allograft recipients (58 males). Before transplantation, all of the recipients were on renal replacement therapy. The immunosuppressive regimen of kidney transplant recipients consisted of a calcineurin inhibitor in combination with mycophenolate mofetil, a mammalian target of rapamycin inhibitor, or prednisone. All subjects maintained sufficient stable graft function, showing no clinical signs of rejection or inflammation. Each subject gave informed
Results
Clinical and biochemical data of kidney allograft recipients are shown in Table 1. The mean serum renalase among recipients was significantly higher compared with the control group (6.72 ± 4.50 µg/mL vs 3.86 ± 0.73 µg/mL; P < .001). In kidney transplant recipients renalase correlated with age (r = 0.29; P < .05), time after transplantation (r = 0.34; P < .01) and systolic blood pressure (r = 0.28; P < .05; Fig 1) as well as diastolic blood pressure (r = 0.27; P < .05), serum creatinine (r =
Discussion
We observed that renalase was significantly higher among kidney transplant recipients compared with healthy volunteers. In addition, renalase content was related to kidney function, age, time after transplantation, serum phosphate, and blood pressure. On multiple regression analysis, renalase level was predicted independently by age, kidney function, time after transplantation, and diastolic blood pressure.
The connection between renalase and hypertension was demonstrated by Zhao et al12 in the
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Cited by (55)
The enzyme: Renalase
2017, Archives of Biochemistry and BiophysicsCitation Excerpt :However, this very fundamental factor has not been independently corroborated [1], despite the fact that renalase has no clear secretion signal (SignalP score of 0.41). There is no disputing that renalase is found in blood [6,7,66,68,75–81], but it has not been established if the enzyme was purposefully secreted by a specific cell type or simply liberated by cell death, as might be expected for basal cell turnover and additively for numerous pathologies, thereby serving as the basis (and inherent limitation) of correlation [16,17,25,71,82–90]. What is apparent is that the most current evidence for the physiological function of renalase, as a delivery vessel for a cyto-active peptide, has severed the link to the observations that initially generated and subsequently sustained research interest in this enzyme, i.e. catecholamine oxidation and blood pressure modulation.
Increased serum renalase in peritoneal dialysis patients: Is it related to cardiovascular disease risk?
2017, NefrologiaCitation Excerpt :In agreement with this finding, other studies also reported higher levels of serum renalase in PD and hemodialysis patients than in healthy volunteers, which were correlated with residual renal function.9,10,15,16 Furthermore, serum renalase levels were negatively correlated with glomerular filtration rates and increased in a graded fashion from CKD stage 2–5 in both CKD and kidney transplant patients.11,17,18 Since renalase is an amine oxidase that metabolizes circulating catecholamines and reduce their plasma levels, experimental and genetic studies proposed a protective effect of renalase in regulation of blood pressure and development of cardiovascular complications in kidney disease patients.
High-performance Liquid Chromatography Measured Metabolites of Endogenous Catecholamines and Their Relations to Chronic Kidney Disease and High Blood Pressure in Heart Transplant Recipients
2016, Transplantation ProceedingsCitation Excerpt :In our study, we did not find a correlation between blood pressure values and the levels of urine catecholamine metabolites and serum renalase. We confirmed previous studies, that renalase was predicted by kidney function [12,24–26]. It suggests that the pathophysiology of hypertension in this group of patients is very complex and multifactorial.
Human urinary renalase lacks the N-terminal signal peptide crucial for accommodation of its FAD cofactor
2015, International Journal of Biological MacromoleculesRenalase, kidney and cardiovascular disease: Are they related or just coincidentally associated?
2015, Advances in Medical Sciences