Renal transplantationComplication: Other problemIncrease in Malignancies as Cause of Death in Renal Transplant Patients
Section snippets
Patients and Methods
Andalusia is a region in the south of Spain with a population of approximately 8 million. Since 1984, the data of all patients who have received hemodialysis, peritoneal dialysis, or a kidney transplant in Andalusia have been collected into a computerized registry. Patient variables have included age, sex, cause of end-stage renal disease (ESRD), viral hepatitis serology, previous renal replacement therapy (RRT) type and extent, organ origin (deceased or living donor), combined solid organ
Results
The total number of patients who died after renal transplantation was 1106, including 656 who died with functioning renal grafts, which constituted the group analyzed in this study. The most frequent cause of death among these 656 patients was cardiovascular disease (n = 184; 28%), followed by infections (n = 149; 22.7%) and malignancies (n = 121; 18.4%), whereas hepatic diseases (n = 37; 5.6%), other (n = 102; 15.5%), and unknown (n = 63; 9.6%) were less prevalent. No significant differences
Discussion
The survival of renal transplant recipients has shown considerable improvement in recent years. This observation is probably due to more experience with pre- and posttransplant clinical management. In particular, it is due to advances in immunosuppressive and antibiotic therapies, in surgical techniques, and in medical treatment of cardiovascular risk factors. The causes of graft loss have also changed over time; currently, death with a functioning graft constitutes one of the principal causes
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Cited by (19)
Determinants of Successful Use of Sirolimus in Renal Transplant Patients
2020, Transplantation ProceedingsCitation Excerpt :Death due to infections was rare in our patient cohort, with 7.5% compared with 22% to 23% in the aforementioned [24] and another large registry study [25]. One explanation is that infection-related death is more prevalent early after transplantation [26], and SRL initiation in our patient cohort occurred on average 6 years after transplantation. Graft failure was responsible for one fourth of therapy failures and occurred in 15% of the whole study cohort, which is comparable with rates of 11% to 17% from reports of smaller studies [27,28].
Renal transplant among type 1 and type 2 diabetes patients in Spain: A population-based study from 2002 to 2013
2017, European Journal of Internal MedicineCitation Excerpt :We detected significant increases in infections over time. Previous research had reported that infections were the most frequent cause of death (> 40%) in the first year post-transplantation despite improvements in treatment and prophylaxis, perhaps due to the use of more powerful immunosuppressive protocols [20]. In spite of this, we are showing decreasing trends in mortality rates during admission for RTx.
Bladder cancer in renal allograft recipients: Risk factors and outcomes
2014, Transplantation ProceedingsResults of the Conversion to Everolimus in Renal Transplant Recipients With Posttransplantation Malignancies
2010, Transplantation Proceedings
This work was supported by grants for data collection from Astellas, Novartis, Roche-Farma, Wyeth, and Genzyme.