Liver transplantationComplicationThe Burden of Chronic Kidney Disease in Long-Term Liver Transplant Recipients
Section snippets
Materials and Methods
This study included all adult patients (18 years of age or older) who received OLT at The Mount Sinai Medical Center from January 1997 to December 1999. The cutoff date for our analysis was January 1, 2005. A total of 502 OLT were performed during this period, and 284 patients (57%) were alive. Of the 284 survivors, 231 patients who were regularly followed at our post-OLT clinic were included in the study. Preoperative variables analyzed were: age, sex, race, body mass index (BMI, defined as
Patient Population
The median follow-up was 73 months (range, 60 to 84 months). There were 231 patients in the study and the patient demographics are shown in Table 1. There were 147 men (64%) and 84 women (36%), Caucasian (67%) and African-American (16%), with a mean age of 56 ± 12 years. The indications for OLT were: hepatitis C virus (HCV; n = 111), primary biliary cirrhosis (n = 32), alcoholic liver disease (n = 23), hepatitis B virus (n = 23), cryptogenic cirrhosis (n = 16), autoimmune hepatitis (n = 10),
Discussion
In this retrospective cohort study of stable OLT patients followed at our center, we found a very high incidence of CKD. Although CKD is common in long-term OLT recipients, previous studies have not clearly defined the exact incidence. In our study, only 10% of OLT recipients had a GFR of more than 90 mL/min, and the mean GFR for the entire population was 56 mL/min (stage III CKD). Hypertension was significantly more prevalent in the CKD group and appeared more difficult to control. These
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Impact of Abdominal Aortic Calcification on Chronic Kidney Disease After Liver Transplantation: A Retrospective Study
2023, Transplantation ProceedingsKidney failure after liver transplantation
2022, Nephrologie et TherapeutiqueAcute kidney injury and chronic kidney disease after liver transplant: A retrospective observational study
2022, NefrologiaCitation Excerpt :Post-transplant CKD is a major public health problem among all non-renal solid organ transplant recipients. Previous studies reported on the occurrence of CKD after LT, with an incidence ranging between 20% and 80%.3–14 In addition to the evidence reported above, this wide range of results is related to other factors such as patient selection, or differences in managing patients, among others.3–14
Clinical usefulness of kidney biopsy in liver transplant recipients with renal impairment
2013, Kidney Research and Clinical PracticeCitation Excerpt :However, until now, only a few reports have used kidney biopsies to investigate the cause of renal impairment, and these studies have had contradictory results. For example, some reports have suggested that calcineurin inhibitor (CNI)-induced nephrotoxicity is the main cause of renal impairment [2–5]. By contrast, other recent reports proposed that kidney pathology after LT is variable and not limited to CNI toxicity [6–8].
Predicting end-stage renal disease after liver transplant
2013, American Journal of Transplantation