Research PaperPolydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway
Under a Creative Commons license
open access
Graphical abstract
Abbreviations
ASC
apoptosis-associated speck-like protein
CPT-1
carnitine palmitoyl transferase-1
GST
glutathione S-transferase
HO-1
hemeoxygenase-1
H2O2
hydrogen peroxide
IL
interleukin
Keap1
Kelch-like ECH-associated protein 1
MDA
malondialdehyde
miR-200a
microRNA-200a
NAC
N-acetyl-L-cysteine
NAFLD
non-alcoholic fatty liver disease
NLRP3
the NOD-like receptor (NLR) family, pyrin domain containing 3
NQO1
NAD(P)H, quinone oxidoreductase 1
Nrf2
nuclear factor erythroid 2-related factor 2
PPAR-α
peroxisome proliferator activated receptor-α
ROS
reactive oxygen species
SCD-1
stearoyl-CoA desaturase-1
SREBP-1
sterol regulatory element binging protein 1
tBHQ
tert-butylhydroquinone
TNF-α
tumor necrosis factor-α
TXNIP
thioredoxin-interacting protein
Keywords
Polydatin
Excess fructose intake
Oxidative stress
MiR-200a
Keap1/Nrf2 pathway
Liver inflammation and lipid deposition
Cited by (0)
© 2018 The Authors. Published by Elsevier B.V.