Elsevier

Kidney International

Volume 93, Issue 3, March 2018, Pages 542-544
Kidney International

Commentary
IgA nephropathy: toward more specific diagnosis (and rescue of snails)

https://doi.org/10.1016/j.kint.2017.10.028Get rights and content
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The diagnosis of IgA nephropathy relies on the histologic demonstration of glomerular mesangial IgA deposits. However, only a very small fraction of IgA, namely, galactose-deficient IgA1, seems to induce the disease. So far, this type of IgA could only be detected using mass spectrometry or lectins, which are relatively difficult to standardize. A novel monoclonal antibody, KM55, specifically recognizing galactose-deficient IgA1, may now change this.

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see clinical investigation on page 700