COVID-19 in a patient with end-stage renal disease on chronic in-center hemodialysis after evidence of SARS-CoV-2 IgG antibodies. Reinfection or inaccuracy of antibody testing
Possible reinfection with SARS-CoV-2 in an ESRD patient with prior positive IgG antibody test against SARS-CoV-2.
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Potential lack of antibody protection after asymptomatic infection in ESRD patients.
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The prospect of antibody dependent enhancement.
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The need for careful interpretation of antibody test in ESRD patients until further understanding of reinfection risk and antibody response.
Abstract
A patient with end-stage renal disease on hemodialysis with a previous positive SARS-CoV-2 IgG antibody was diagnosed with severe COVID-19. Issues regarding reinfection, the potential lack of antibody protection after asymptomatic infection, the possibility of antibody dependent enhancement and careful interpretation of antibody test results are discussed.