Elsevier

Environment International

Volume 64, March 2014, Pages 83-90
Environment International

Review
Bisphenol A and human chronic diseases: Current evidences, possible mechanisms, and future perspectives

https://doi.org/10.1016/j.envint.2013.12.007Get rights and content
Under a Creative Commons license
open access

Highlights

  • Implication of bisphenol A in the etiology of some human chronic diseases.

  • Genetic, epigenetic and endocrine disruptions are the major possible mechanisms of action.

  • Public sensitization programs should be set up especially in developing countries.

Abstract

Bisphenol-A (BPA) is one of the highest volume chemicals produced worldwide, with over 6 billion pounds produced and over 100 t released into the atmosphere each year. Recent extensive literature has raised concerns about its possible implication in the etiology of some human chronic diseases such as diabetes, obesity, reproductive disorders, cardiovascular diseases, birth defects, chronic respiratory and kidney diseases and breast cancer. In this review, we present the highlighted evidences on the relationship between BPA exposure and human chronic diseases and we discuss its eventual mechanisms of action, especially genetic, epigenetic and endocrine disruption mechanisms with the possible involvement of oxidative stress, mitochondrial dysfunction and cell signaling.

Abbreviations

AR
androgen receptor
BPA
bisphenol A
CpG
cytosine-guanine dinucleotide
DNMT
DNA methyltransferases
ER
estrogen receptor
ERK
extracellular signal-regulated kinase
ERR-γ
estrogen-related receptor gamma
GPR 30
G protein-coupled receptor 30
GR
glucocorticoid receptor
IVF
In vitro fertilization
JNK
c-Jun N-terminal kinase
LOAEL
lowest observed adverse effect level
NF-κb
nuclear factor-kappa B
POP
persistent organic pollutant
TDI
tolerable daily intake
THR
thyroid hormone receptor

Keywords

Bisphenol A
Chronic human diseases
Etiology
Mechanisms

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