Cell Metabolism
Volume 23, Issue 6, 14 June 2016, Pages 1060-1065
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Essay
Metformin as a Tool to Target Aging

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Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.

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