Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Volume 1803, Issue 12, December 2010, Pages 1386-1395
Jagged/Notch signalling is required for a subset of TGFβ1 responses in human kidney epithelial cells
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Research Highlights
►Jagged/Notch signalling is required for a subset of TGFβ1-regulated EMT genes in kidney epithelial cells. ►Upregulation of Jagged1 and Hes1 precedes changes in EMT genes such as E-cadherin. ►Inhibition of Jagged/Notch signalling prevents TGFβ1-induced changes in cell shape. ►Jagged1 upregulation by TGFβ1 is completely Smad3 dependent, and partially PI3K/ERK dependent.
Keywords
Kidney epithelial cell
Jagged Notch pathway
gamma-Secretase
Transforming growth factor beta
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These authors contributed equally to this work.
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