Valvular Heart DiseaseRelation of Aortic Valve Calcium to Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study)
Section snippets
Methods
The CRIC study population is a racially and ethnically diverse cohort of men and women aged 21 to 74 years with mild-to-moderate renal disease, approximately half of which have diabetes. The CRIC participants were recruited from May 2003 to August 2008 from 7 clinical centers in the United States.2 The identification of subjects was facilitated through searches of laboratory databases, medical records, and referrals from health care providers. Subjects with cirrhosis, HIV infection, polycystic
Results
Table 1 summarizes demographics and baseline characteristics from the CRIC database participants who underwent baseline CT with calcium scoring of their aortic valves (n = 1,964). The participants were grouped based on the presence and severity of AVC. Increasing age, body mass index, waist circumference, blood pressure, cholesterol, hemoglobin A1c, and decreased physical activity and a history of diabetes, hypertension, or cardiovascular disease were all independently associated with increased
Discussion
To our knowledge, this study is the first to show a statistically significant correlation between non–end-stage CKD and AVC and to identify associations between traditional and novel cardiovascular risk factors and derangements in bone metabolisms and AVC in patients with early stages of CKD. In addition to confirming the relation between traditional cardiovascular risk factors and increased AVC in patients with CKD, the unadjusted analysis also identified decreased eGFR as independently
Disclosures
Funding for the CRIC Study was obtained under a co-operative agreement from the National Institute of Diabetes and Digestive and Kidney Diseases (U01DK060990, U01DK060984, U01DK061022, U01DK061021, U01DK061028, U01DK060980, U01DK060963, and U01DK060902, Bethesda, MD). In addition, this work was supported in part by the Perelman School of Medicine at the University of Pennsylvania Clinical and Translational Sciences Award NIH NCATS UL1TR000003 (Philadelphia, PA), Johns Hopkins University UL1
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See page 1286 for disclosure information.
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CRIC Study Investigators include Lawrence J. Appel, MD, MPH, Harold I. Feldman, MD, MSCE, Alan S. Go, MD, Jiang He, MD, PhD, John W. Kusek, PhD, James P. Lash, MD, Mahboob Rahman, MD, and Raymond R. Townsend, MD.