MiscellaneousEffect of Pre-Eclampsia–Eclampsia on Major Cardiovascular Events Among Peripartum Women in Taiwan
Section snippets
Methods
Data for this study were obtained from 3 main sources. The first source was birth registries from 1999 to 2003 provided by the ministry of the interior. This dataset contains comprehensive information about birth and parents' data, including age, education, marital status, infant birth weight, gestational weeks, infant sex, and multiple births. The second source was the NHI hospital discharge data covering 1996 to 2004, a nationwide population-based data including >21 million enrollees,
Results
There were 1,132,064 pregnancies identified during the study period; of these 68% of mothers were ∼25 to 34 years old, 97% of pregnancies were single gestation and 46% were nulliparous, and 724 cases of MACEs occurred from the third trimester of pregnancy to the end of 2004. Table 1 presents the distribution of MACE cases among sociodemographic and clinical groups.
Overall incidence of any MACE was 16.21 per 100,000 patients per year, of which >70% consisted of stroke cases. Heart failure was
Discussion
Different epidemiologic studies have demonstrated that women with pre-eclampsia/eclampsia develop complications with cardiovascular disease compared to a normal population.1, 2, 3, 4, 5, 6, 7, 8, 9 In 2001, from a cohort study of 129,290 pregnant women with 15-year follow-up, Smith et al3 found a strong correlation between complicated pregnancies and maternal risk of ischemic heart disease. Women with pre-eclampsia, preterm birth, and low birth weight were found to have a 16-fold higher risk
Acknowledgment
The authors thank the NHI bureau for its technical assistance in processing data for this study. Special thanks also go to Chien-Jen Chen, PhD, and San-Lin You, PhD, at Genomics Research Center, Academia Sinica, Taipei, Taiwan, and to Yi-Hua Chen, PhD, School of Public Health, Taipei Medical University, Taipei, Taiwan, for their advice on statistical analysis.
References (16)
- et al.
Pregnancy complications and maternal risk of ischaemic heart disease: a retrospective cohort study of 129,290 births
Lancet
(2001) - et al.
Preeclampsia: at risk for remote cardiovascular disease
Am J Med Sci
(2007) - et al.
Cardiovascular sequelae of preeclampsia/eclampsia: a systematic review and meta-analyses
Am Heart J
(2008) - et al.
Pathogenesis and genetics of pre-eclampsia
Lancet
(2001) - et al.
The influence of adolescent body mass index, physical activity, and tobacco use on blood pressure and cholesterol in young adulthood
J Adolesc Health
(2008) - et al.
Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia
Lancet
(2003) - et al.
Pathophysiology of hypertension in response to placental ischemia during pregnancy: a central role for endothelin?
Gend Med
(2008) - et al.
Preeclampsia-eclampsia and the risk of stroke among peripartum in Taiwan
Stroke
(2009)
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This work was supported by Grants NHRI-EX95-9108SC and NHRI-EX969627SI from the National Health Research Institute, Taiwan; Grants NSC 96-2314-B182-026 and 97-2314-B-182-028-MY2 from the National Science Council, Taipei, Taiwan; Topnotch Stroke Research Center, Ministry of Education, Taipei, Taiwan; and Grant DOH-TD-B-111-002 from the Center of Excellence for Clinical Trial and Research in Neurology and Neurosurgery, Department of Health, Taipei, Taiwan.
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Dr. Lin and Dr. Tang contributed equally to this work.