TY - JOUR T1 - Haptoglobin genotype and risk of diabetic nephropathy in patients with type 1 diabetes mellitus: a study on a Spanish population JO - Nefrología (English Edition) T2 - AU - Amor,Antonio J. AU - Canivell,Silvia AU - Oriola,Josep AU - Ricart,Maria J. AU - de Hollanda,Ana M. AU - Bosch-Comas,Anna AU - Esmatjes,Enric SN - 20132514 M3 - 10.3265/Nefrologia.pre2014.Feb.12034 DO - 10.3265/Nefrologia.pre2014.Feb.12034 UR - https://revistanefrologia.com/en-haptoglobin-genotype-risk-diabetic-nephropathy-articulo-X2013251414053760 AB - Background: Few reports have studied the possible association between the haptoglobin (Hp) genotype and the risk of diabetic nephropathy (DN) in type 1 diabetes (T1D), with conflicting results to date. Aims: To study whether the 2-2 Hp genotype is associated with an increased risk of overt DN in a Spanish population with T1D. Methods: We performed a case-control study in a Spanish population. CASES: T1D patients with end-stage renal disease (stage 5 of NKF-KDOQI), awaiting reno-pancreatic transplantation or having already been transplanted (reno-pancreatic or renal alone). CONTROLS: T1D patients, matched for sex and time of diabetes evolution, with preserved renal function and normal urinary albumin excretion. Hp genotyping was done using polymerase chain reaction and electrophoresis. Results: We included 57 cases and 57 controls in the study. There were no statistically significant differences in gender (70% vs. 61% males, p=1.0) or the duration of diabetes (23.0±6.7 vs. 20.8±9.3 years; p=0.1), although the age of onset of diabetes was lower in the cases (14.1±6.8 vs. 17.7±10.1 years, p=0.03). The frequency of genotypes 1-1, 1-2 and 2-2 was 19.3%, 42.1% and 38.6% in cases and 17.5%, 49.1% and 33.4% in controls, respectively, with no statistically significant differences between groups (p=0.8). Conditional logistic regression analysis showed no significant association between genotype 2-2 of Hp and the development of DN (OR 1.14, CI 0.52-2.52). Conclusions: In our sample of a Spanish population with T1D, no association was found between the Hp genotype and risk of overt DN. ER -