TY - JOUR T1 - Acute kidney injury in hospitalized patients with COVID-19: A Portuguese cohort JO - Nefrología (English Edition) T2 - AU - Gameiro,Joana AU - Fonseca,José Agapito AU - Oliveira,João AU - Marques,Filipe AU - Bernardo,João AU - Costa,Claudia AU - Carreiro,Carolina AU - Braz,Sandra AU - Lopes,José António SN - 20132514 M3 - 10.1016/j.nefroe.2022.01.007 DO - 10.1016/j.nefroe.2022.01.007 UR - https://revistanefrologia.com/en-acute-kidney-injury-in-hospitalized-articulo-S2013251422000098 AB - IntroductionThe incidence of acute kidney injury (AKI) in coronavirus disease 2019 (COVID-19) patients ranges from 0.5% to 35% and has been associated with worse prognosis. The purpose of this study was to evaluate the incidence, severity, duration, risk factors and prognosis of AKI in hospitalized patients with COVID-19. MethodsWe conducted a retrospective single-center analysis of 192 hospitalized COVID-19 patients from March to May of 2020. AKI was diagnosed using the Kidney Disease Improving Global Outcome (KDIGO) classification based on serum creatinine (SCr) criteria. Persistent and transient AKI were defined according to the Acute Disease Quality Initiative (ADQI) workgroup definitions. ResultsIn this cohort of COVID-19 patients, 55.2% developed AKI (n=106). The majority of AKI patients had persistent AKI (n=64, 60.4%). Overall, in-hospital mortality was 18.2% (n=35) and was higher in AKI patients (28.3% vs. 5.9%, p<0.001, unadjusted OR 6.03 (2.22–16.37), p<0.001). In this multivariate analysis, older age (adjusted OR 1.07 (95% CI 1.02–1.11), p=0.004), lower Hb level (adjusted OR 0.78 (95% CI 0.60–0.98), p=0.035), duration of AKI (adjusted OR 7.34 for persistent AKI (95% CI 2.37–22.72), p=0.001) and severity of AKI (adjusted OR 2.65 per increase in KDIGO stage (95% CI 1.32–5.33), p=0.006) were independent predictors of mortality. ConclusionAKI was frequent in hospitalized patients with COVID-19. Persistent AKI and higher severity of AKI were independent predictors of in-hospital mortality. ER -