TY - JOUR T1 - Calciphylaxis in patients with chronic kidney disease: A disease which is still bewildering and potentially fatal JO - NefrologĂ­a (English Edition) T2 - AU - Cucchiari,David AU - Torregrosa,Jose-Vicente SN - 20132514 M3 - 10.1016/j.nefroe.2018.09.001 DO - 10.1016/j.nefroe.2018.09.001 UR - https://revistanefrologia.com/en-calciphylaxis-in-patients-with-chronic-articulo-S2013251418301068 AB - Calciphylaxis, also known as calcific uremic arteriolopathy, is a rare syndrome that typically causes skin necrosis and usually affects dialysis patients. Its pathogenesis is multifactorial and is the consequence of many factors causing ectopic calcifications in patients with chronic kidney disease, such as calcium-phosphate metabolism disorders, hyper- or hypo-parathyroidism, diabetes, obesity, systemic inflammation and the use of vitamin K antagonists, among others. From a clinical point of view, calciphylaxis may progress from painful purpura to extensive areas of skin necrosis that can potentially lead to superinfection and the death of the patient due to sepsis. Treatment is primarily based on managing the wounds, eliminating all the possible precipitating factors of ectopic calcification and administering agents which are capable of inhibiting the process of calcification. ER -