TY - JOUR T1 - Postdiarrhoeal haemolytic uraemic syndrome without thrombocytopenia JO - Nefrología (English Edition) T2 - AU - Balestracci,Alejandro AU - Toledo,Ismael AU - Meni Battaglia,Luciana AU - de Lillo,Leonardo AU - More,Natalia AU - Cao,Gabriel AU - Alvarado,Caupolican SN - 20132514 M3 - 10.1016/j.nefroe.2017.09.001 DO - 10.1016/j.nefroe.2017.09.001 UR - https://revistanefrologia.com/en-postdiarrhoeal-haemolytic-uraemic-syndrome-without-articulo-S2013251417301451 AB - BackgroundThrombocytopenia is a hallmark of postdiarrhoeal haemolytic uraemic syndrome (D+ HUS), although it can be transient and therefore undetected. There is scarce information regarding the prevalence and the course of the disease in children with D+ HUS without thrombocytopenia. ObjectiveTo determine the prevalence of D+ HUS without thrombocytopenia and to describe the clinical characteristics of a series of children with this condition. Patients and methodsThe medical records of patients with D+ HUS hospitalised between 2000 and 2016 were reviewed to identify those without thrombocytopenia (>150,000mm3). Demographic, clinical and laboratory parameters of the selected cases were collected and descriptively analysed. ResultsNine cases (5.6%) without thrombocytopenia were identified among 161 patients hospitalised during the study period. Median age at diagnosis was 17 months (7–32) and median prodromal symptom duration was 15 days (7–21). Eight patients maintained normal urine output while the remaining one required dialysis. No patient presented with severe extrarenal compromise and/or hypertension. ConclusionsThe prevalence of non-thrombocytopenic D+ HUS was 5.6% and most cases occurred with mild forms of the disease; however, the need for dialysis in one of them indicated that normalisation of platelet count is not always an accurate marker for disease remittance. Our results also confirm that the time of onset of D+ HUS in patients without thrombocytopenia is usually delayed with respect to the initial intestinal symptoms; thus, heightened diagnostic suspicion is necessary. ER -