TY - JOUR T1 - Estimation of the glomerular filtration rate in people older than 85: Comparisons between CKD-EPI, MDRD-IDMS and BIS1 equations JO - Nefrología (English Edition) T2 - AU - Bustos-Guadaño,Fernando AU - Martín-Calderón,José Luis AU - Criado-Álvarez,Juan José AU - Muñoz-Jara,Raquel AU - Cantalejo-Gutiérrez,Adolfo AU - Mena-Moreno,María Concepción SN - 20132514 M3 - 10.1016/j.nefroe.2017.04.011 DO - 10.1016/j.nefroe.2017.04.011 UR - https://revistanefrologia.com/en-estimation-glomerular-filtration-rate-in-articulo-S2013251417300834 AB - BackgroundThe evidence of glomerular filtration rate (GFR) estimating with serum creatinine based formulae in the elderly population is scarce. The purpose of this study is to compare CKD-EPI, MRD4-IDMS and BIS1 equations to analyze correlation and concordance in a population older than 85 years old. Patients and methodsWe designed a retrospective cross-sectional study, which included data from 600 patients older than 85 years. GFR was estimated by the following equations: CKD-EPI, MDR4-IDMS and BIS1, using as variables sex, age and serum creatinine concentration. Statistics analysis included Wilcoxon test, Bland–Altman plot, non-parametric Passing–Bablok method and kappa statistic (simple and weighted). ResultsThe patients’ median (range) age was 87 (interval 85–98). The median GFR (range) was 42.4 (5.2–127.4)mL/min/1.73m2, when it was estimated with MDRD-IDMS, 40.0 (4.5–93.1) for CKD-EPI and 36.9 (7.6–83.7) for BIS1. The comparison of BIS1 and CKD-EPI and MDRD-IDMS using the Wilcoxon test was significant (p<0.001). The regression analysis yielded the following equations: MDRD-IDMS=1.025×CKD-EPI+1.360; BIS1=0.688×CKD-EPI+9.074 and BIS1=0.666×MDRD-IDMS+8.401. The weighted coefficient was 0.958 for the concordance between MDRD-IDMS and CKD-EPI, 0.812 for the concordance between MDRD-IDMS and BIS1 and 0.846 for CKD-EPI and BIS1. ConclusionsThe GFR estimations obtained with BS1 equation are not interchangeable with MDRD-IDMS or CKD-EPI equations. BIS1 estimates lower GFR values than MDRD-IDMS and CKD-EPI and tends to classify the patients in a more advanced chronic kidney disease stage, especially for estimated GFR higher than 29mL/min/1.73m2. ER -