TY - JOUR T1 - Randomised intervention study to assess the prevalence of subclinical vascular disease and hidden kidney disease and its impact on morbidity and mortality: The ILERVAS project JO - Nefrología (English Edition) T2 - AU - Betriu,Àngels AU - Farràs,Cristina AU - Abajo,María AU - Martinez-Alonso,Montserrat AU - Arroyo,David AU - Barbé,Ferran AU - Buti,Miquel AU - Lecube,Albert AU - Portero,Manuel AU - Purroy,Francisco AU - Torres,Gerard AU - Valdivielso,José Manuel AU - Fernández,Elvira SN - 20132514 M3 - 10.1016/j.nefroe.2016.07.006 DO - 10.1016/j.nefroe.2016.07.006 UR - https://revistanefrologia.com/en-randomised-intervention-study-assess-prevalence-articulo-S2013251416300682 AB - Background and objectivesChronic kidney disease (CKD) and atherosclerosis are 2 interrelated diseases that increase the risk of cardiovascular morbidity and mortality. The objectives of the ILERVAS project are: (1) to determine the prevalence of subclinical arterial disease and hidden kidney disease; (2) to assess the impact of early diagnosis of both diseases on cardiovascular morbidity and mortality and also on the progression of CKD; (3) to have a platform of data and biological samples. MethodsRandomised intervention study. From 2015 to 2017, 19,800 people (9900 in the intervention group and 9900 in the control group) aged between 45 and 70 years without previous history of cardiovascular disease and with at least one cardiovascular risk factor will be randomly selected from the primary health care centres across the province of Lleida. A team of experts will travel around in a mobile unit to carry out the following baseline tests on the intervention group: Artery ultrasound, (carotid, femoral, transcranial and abdominal aorta), ankle-brachial index, spirometry, determination of advanced glycation end products, dried blood spot and urine spot tests. Additionally, blood and urine samples will be collected and stored in the biobank to identify new biomarkers using omics studies. Participants will be followed up until 2025 for identification of cardiovascular events, treatment changes and changes in lifestyle. ConclusionsThe ILERVAS project will reveal the prevalence of subclinical vascular disease and hidden kidney disease, determine whether or not their early diagnosis brings health benefits and will also allow investigation of new risk factors. ER -