TY - JOUR T1 - Correlation between the protein/creatinine ratio in spot urine and 24-hour urine protein JO - Nefrología (English Edition) T2 - AU - Montero,Nuría AU - Montero,Nuria AU - Soler,María José AU - Soler,M. José AU - Pascual,María José AU - Pascual,M. José AU - Barrios,Clara AU - Márquez,Eva AU - Rodríguez,Eva AU - Berrada,Ali AU - Riera,Marta AU - Coca,Lluis AU - Coca,Lluís AU - Orfila,María Antonia AU - Orfila,M. Antonia AU - Pascual,Julio SN - 20132514 M3 - 10.3265/Nefrologia.pre2012.Apr.11300 DO - 10.3265/Nefrologia.pre2012.Apr.11300 UR - https://revistanefrologia.com/en-correlation-between-protein-creatinine-ratio-in-articulo-X2013251412001579 AB - Introduction: Measurement of the protein content in a 24-hour urine sample is the definitive method of establishing the presence of abnormal proteinuria. However, the urine collection is cumbersome. The spot urine protein to creatinine ratio seems to be a reliable diagnostic tool for urine protein measurement. Objective: Our aim was to evaluate the spot urine protein/creatinine ratio against 24-h urine total protein excretion in different proteinuria ranges by comparing samples collected simultaneously in patients of Hospital del Mar during the last year. Material and method: Observational, cross-sectional study of 159 consecutive paired determinations of 24-h urine total protein excretion and the spot urine protein/creatinine ratio (P/C) in renal patients. The strength of the correlation was determined by calculating the intraclass correlation coefficient (ICC) and the Spearman correlation coefficient (SCC). Results: Among all groups, there was a significant correlation between 24-hour proteinuria and the P/C ratio (SCC: r=0.91, P<0.001). The correlation in different levels of proteinuria were: <300mg (SCC: r=0.498, P<0.001; ICC: 0.46), 300-3499mg (SCC: r=0.828, P<0.001; ICC: 0.66) and ≥3500mg (SCC: r=0.181, P=NS; ICC: 0.18). Conclusions: In summary, a strong correlation was observed between spot urine protein/creatinine ratio and 24-h urine total protein excretion in proteinuria levels from 300mg/day to 3499mg/day. A lower correlation was also maintained in 24-h urine total protein <300mg. In our experience, there is no relevant correlation between spot urine protein/creatinine ratio and 24-h urine total protein excretion in nephrotic-range proteinuria.  ER -